| Autor: |
Kang, Seung Wan, Jeong, Won Gi, Lee, Jong Eun, Oh, In-Jae, Song, Sang Yun, Lee, Byung Chan, Kim, Yun-Hyeon |
| Předmět: |
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| Zdroj: |
Acta Radiologica; Mar2023, Vol. 64 Issue 3, p1028-1037, 10p |
| Abstrakt: |
Background: While the central location is a known adverse prognostic factor in lung cancer, a precise definition of central lung cancer has not yet emerged. Purpose: To determine the prognostic significance of central lung cancer (defined by location index) in resected T1-sized early-stage non-small cell lung cancer (NSCLC). Material and Methods: Patients with resected T1-sized early-stage NSCLC between 2010 and 2015 at a single tertiary cancer center were retrospectively reviewed. Central lung cancer was defined by a location index of the second tertile or less. Kaplan–Meier analysis with log-rank test and multivariable Cox regression analysis were performed to analyze the relationship between central lung cancer and the prognosis of relapse-free survival (RFS) and overall survival (OS). Inter-observer agreement was assessed using Cohen's kappa value and intraclass correlation coefficient (ICC). Results: Overall, 289 patients (169 men; median age 65 years; interquartile range 58–70 years) were evaluated. Central lung cancer (defined by location index) was adversely associated with RFS (P = 0.005) and OS (P = 0.01). Multivariable Cox regression analysis showed that central lung cancer was independently associated with poor RFS (adjusted hazard ratio 1.91; 95% confidence interval [CI] 1.12–3.24; P = 0.017) and OS (adjusted hazard ratio 1.69; 95% CI 1.04–2.74; P = 0.033). Location index demonstrated excellent inter-observer agreement (Cohen's kappa value 0.88; 95% CI 0.82–0.93) with a high ICC (0.98; 95% CI 0.97–0.98). Conclusion: Central lung cancer defined by a location index of the second tertile or lower is an independent adverse prognostic factor in resected T1-sized early-stage NSCLC. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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