Ex Vivo Analysis of an Association of Mechanical Strength of Dilated Ascending Aorta with Tissue Matrix Metalloproteinases and Cytokines.

Autor: Sazonova, S. I., Saushkin, V. V., Panfilov, D. S., Gusakova, A. M., Shipulin, V. V., Maltseva, A. N., Bazarbekova, B. A., Kozlov, B. N.
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Zdroj: Bulletin of Experimental Biology & Medicine; Feb2023, Vol. 174 Issue 4, p497-501, 5p
Abstrakt: We analyzed the associations of the mechanical strength of dilated ascending aorta wall (intraoperative samples from 30 patients with non-syndromic aneurysms) with tissue MMPs and the cytokine system. Some samples were stretched to break on an Instron 3343 testing machine and the tensile strength was calculated; others were homogenized and the concentrations of MMP-1, MMP-2, MMP-7, their inhibitors (TIMP-1 and TIMP-2), and pro- and anti-inflammatory cytokines were determined by ELISA. Direct correlations between aortic tensile strength and concentrations of IL-10 (r=0.46), TNFα (r=0.60), and vessel diameter (r=0.67) and an inverse correlation with patient's age (r=-0.59) were revealed. Compensatory mechanisms supporting the strength of the ascending aortic aneurysm are possible. No associations of MMP-1, MMP-7, TIMP-1, and TIMP-2 with tensile strength and aortic diameter were found. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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