| Autor: |
Convit, J., Pinardi, M. E., Rodríguez Ochoa, G., Ulrich, M., Avila, J. L., Goihman, M. |
| Předmět: |
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| Zdroj: |
Clinical & Experimental Immunology; Jun1974, Vol. 17 Issue 2, p261-265, 5p |
| Abstrakt: |
This investigation studied the possibility or activating lepromatous macrophages by a local `in vivo' test. Lepromatous macrophages have an evident incapacity for clearing M. leprae. This is demonstrated by injecting lepromatous patients with an antigen containing M. leprae from human tissue at a concentration of 640 × 106 bacteria per ml. This produces a nodule which, at a 30-day biopsy, shows a macrophagic granuloma with numerous bacteria inside the macrophages, proving that these cells are unable to remove M. leprae. This incapacity is specific for M. leprae, and all other mycobacteria produce a different reaction. Local `in vivo" stimulation of the lepromatous macrophage was obtained by injecting M. leprae in the same concentration as above but mixed with other mycobacteria (M. lepraemurium or BCG). The mixed antigens produced a tuberculoid granuloma with abundant lymphoid cells. Fite-Faraco stains showed almost no acid-fast bacteria. Therefore, our mixture of antigens had activated the macrophages locally and made them competent for clearing M. leprae. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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