| Autor: |
Santos, Sheila Gabriel, Souza, Marília Cristina Oliveira, Barbosa-Junior, Fernando, Prodocimo, Maritana Mela, Marcondes, Fellip Rodrigues, Almeida, William, Cestari, Marta Margarete, Souza-Bastos, Luciana Rodrigues, Martino-Andrade, Anderson Joel, Guiloski, Izonete Cristina |
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| Zdroj: |
Environmental Science & Pollution Research; Feb2023, Vol. 30 Issue 10, p27996-28009, 14p |
| Abstrakt: |
The presence of phthalates constitutes a risk to the health of aquatic environments and organisms. This work aimed to evaluate the toxic effects of di-iso-pentyl-phthalate (DiPeP) at environmentally relevant concentrations of 5, 25, and 125 µg/L in Danio rerio after subchronic exposure for 14 days. DiPeP altered the antioxidant system in the liver (125 μg/L), intestine (25 μg/L), brain, and gills in all concentrations tested. In animals exposed to 125 μg/L, DNA damage was identified in the gills. In addition, loss of cell boundary of hepatocytes, vascular congestion, necrosis in the liver, and presence of immune cells in the intestinal lumen were observed. Erythrocytic nuclear alterations in the blood occurred in animals exposed to 25 μg/L. DiPeP was quantified in muscle tissue at all exposure concentrations, appearing in a concentration-dependent manner. Contaminants such as DiPeP will still be used for a long time, mainly by industries, being a challenge for industry versus environmental health. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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