| Autor: |
Ruest, Louis-Bruno, Kedzierski, Rafal, Yanagisawa, Masashi, Clouthier, David |
| Předmět: |
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| Zdroj: |
Cell & Tissue Research; Mar2005, Vol. 319 Issue 3, p447-453, 7p |
| Abstrakt: |
Signaling from the endothelin-A (Ednra) receptor is responsible for initiating multiple signaling pathways within neural crest cells (NCCs). Loss of this initiation is presumably the basis for the craniofacial defects observed inEdnra-/- embryos. However, it is not known whether continued Ednra signaling in NCC derivatives is required for subsequent development of the lower jaw. To address this question, mice containingloxP recombination sequences flanking a portion of theEdnragene were bred with transgenic mice that expressCrerecombinase under control of aDlx5/6enhancer element. We find that whileEdnragene inactivation within the mandibular arch of these Ednra conditional knockout embryos is detectable by embryonic day (E) 10.5, mandibular arch-specific gene expression is normal, as is overall mandible development. These results suggest that while Ednra receptor signaling is crucial for early NCC patterning, subsequent Ednra signaling is not essential for mandible bone development. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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