| Abstrakt: |
BACKGROUND: Proton MR spectroscopy (H1-MRS) is currently considered a useful technique for evaluating axonal damage and demyelination in MS; however, only few spectroscopic cervical MS studies have been published because of the technical difficulties. To assess the diagnostic role of MRS in evaluation of MS patients and to evaluate metabolic profile in spinal cord MS plaques as well as NAWM. Methods: a comparative study between MS cases and control group in which twenty patients with multiple sclerosis were encountered in the study and subjected to clinical assessment including full history taking, clinical examination and imaging assessment by conventional MRI and functional MRI. Additional 20 healthy control individuals of the same age and gender group were included in the study. We determined the metabolic profile of each case and compared it with the control group. Results: comparison of the main metabolite ratios between different studied groups (MS cord plaque group and control group), Cho/Cr, NAA/Cr, mI/Cr, and NAA/Cho of control group were 0.52 ± 0.1, 1.1 ± 0.15, 1.4 ± 0.13, and 3.9 ± 0.9, acute MS group were 0.62 ± 0.08, 1.3 ± 0.02, 2.3 ± 0.2, and 2.0 ± 0.04, relapsing MS group were 0.55 ± 0.06, 1.4 ± 0.1, 1.6 ± 0.3, and 1.4 ± 0.08 and progressive MS group were 0.59 ± 0.02, 0.9 ± 0.03, 2.08 ± 0.04, and 1.2 ± 0.06 with P value < 0.001. Conclusions: to evaluate the diagnostic role of MRS in the evaluation of MS patients and to evaluate the metabolic profile in spinal cord MS plaques as well as normal-appearing white matter. [ABSTRACT FROM AUTHOR] |
