| Autor: |
Said, Nora M., El-Nemr, Dina M., Ebrahim, Hoda A., Hussien, Sameh A., Saad, Asmaa A. |
| Předmět: |
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| Zdroj: |
Zagazig University Medical Journal; 2023 Supplement, Vol. 29, p29-37, 9p |
| Abstrakt: |
Background: Bronchial asthma (BA) is a serious worldwide health problem affecting all ages. Its frequency is increasing in many nations, particularly among children. Deficiency in Vitamin D and single nucleotide polymorphisms (SNP) in gene coding vitamin D receptor (VDR) have been associated with asthma. This study aimed to assess the role of serum vitamin level and VDR SNP fok1 rs 10735810 as predictors of therapy response in asthmatic children. Methods: 96 subjects were included in the study; classified into (32 children with controlled bronchial asthma, 32 children with uncontrolled bronchial asthma and 32 healthy children). All children were subjected to serum vitamin D level measurement and Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) for VDR gene FokI polymorphism. Results: There was statistical significant difference (P< 0.001) between the three studied groups as regard vitamin D levels. While, there was no statistically significant association (P=0.05) between vitamin D levels and GINA treatment steps. Regarding VDR FOK1, there was statistically significant difference (P< 0.001) between the asthmatic and healthy control groups regarding the frequency of both Ff and FF genotypes with a p value of (0.027 & 0.002 respectively). Also, there was statistically significant association (P<0.05) between VDR polymorphism and GINA treatment steps. Conclusions: The vitamin D deficiency was higher in children with controlled and uncontrolled asthma, in comparison to the healthy controls. There was a significant association between FOK1 polymorphism and both association of asthma and GINA treatment steps. This suggests that VDR fok1 gene polymorphism might have a role in response to asthma treatment. Keywords: Bronchial asthma; 25OHD; FOK1; vitamin D receptor. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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