| Autor: |
Momenah, Maha Abdullah, Almutairi, Layla Awad, Alqhtani, Haifa Ali, Al-Saeed, Fatimah A., Syaad, Khalid M. Al, Alhag, Sadeq K., Al-qahtani, Mohammed A., Hakami, Zaki Hussain, Mallick, Jewel, Ahmed, Ahmed Ezzat |
| Předmět: |
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| Zdroj: |
Evidence-based Complementary & Alternative Medicine (eCAM); 2/10/2023, p1-5, 5p, 2 Color Photographs, 1 Diagram, 1 Graph |
| Abstrakt: |
Esculentosides include a group of plant-derived compounds with tremendous pharmacological potential. The antiproliferative effects of esculentoside A against different colorectal cancer cells were evaluated. We found that the proliferation of all the colorectal cancer cells was halted by esculentoside A. The IC50 of esculentoside A ranged from 16 to 24 μM against different colorectal cancer cells. Investigation of the underlying molecular mechanism revealed that esculentoside A caused an increase in the colorectal cancer cells at the G1 phase of the cell cycle, indicative of G0/G1 cell cycle arrest. The percentage of G1 cells increased from 22.68% in control to 54.23% at 16 μM esculentoside A. We also found that the colony formation of HT-29 cells was inhibited by 59% at 24 μM esculentoside A. Finally, effects of esculentoside A on the motility of HT-29 colorectal cancer cells were investigated, and it was found that esculentoside A caused a significant decline in HT-29 colorectal cancer cell migration and invasion. The migration and invasion of esculentoside A-treated HT-29 cells were 45% and 51% higher, respectively, than those of untreated cells. Summing up, these results suggest that esculentoside A exhibits antiproliferative effects against human colorectal cancer cells. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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