Direct Use of Copper-Containing Minerals in Goldberg Arylation of Amides.

Autor:	Györke, Gábor, Dancsó, András, Volk, Balázs, Bezúr, László, Hunyadi, Dávid, Szalóki, Imre, Milen, Mátyás
Předmět:	ARYLATION MINERALS AMIDES IODOBENZENE AMIDE derivatives CATALYSIS
Zdroj:	Catalysis Letters; Feb2023, Vol. 153 Issue 2, p503-521, 19p
Abstrakt:	Copper-containing minerals are among the most abundant minerals on Earth. They play a fundamental role in our economy and, as presented in prebiotic studies, in the origin of life. Over 700 copper-containing minerals are present in nature with well-defined structure and formula. By utilizing the catalytic effect of such minerals, highly economical and green methods can be developed. One of such methods is presented in this study in copper mineral-catalyzed Goldberg arylation reactions of amides. A total of seven readily available minerals were tested in the reaction of iodobenzene with pyrrolidin-2-one with chrysocolla [(Cu,Al)2H2Si2O5(OH)4·n H2O] and malachite [Cu2(CO3)(OH)2] being the best applicable ones. After optimization, a wide variety of arylated amide derivatives were synthesized utilizing the catalytical effect of the above-mentioned minerals. The procedure proved to be feasible regardless of the origin of the catalyst making this method even more attractive. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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