| Autor: |
Keckstein, Julia S., Keckstein, Simon, Brunecker, Kristin, Neugebauer, Alexander, Nüssle, Daniela, Hoffmann, Sascha, Andress, Jürgen, Neis, Felix, Scharpf, Marcus, Enderle, Markus, Rothmund, Ralf, Brucker, Sara Y., Jun, Martin Weiss, Kraemer, Bernhard |
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| Zdroj: |
Archives of Gynecology & Obstetrics; Jan2023, Vol. 307 Issue 1, p187-194, 8p |
| Abstrakt: |
Purpose: Endometriosis is a benign, but potentially serious gynaecological condition in terms of abdominal pain and impaired fertility. Laparoscopic excision techniques are considered the therapeutic standard. HybridAPC is presented as a novel technique for the non-contact thermal ablation of peritoneal endometriosis with simultaneous protection of the underlying thermosensitive structures by creating a needle-free elevated fluid cushion which enables a safer exposure and distance, as well as potentially improved peritoneal conditioning prior to APC. Methods: In this prospective randomized clinical trial, 39 patients with 132 superficial endometriotic lesions in total were treated with HybridAPC or sharp excision in an initial laparoscopic procedure according to randomization. In a second-look laparoscopy, adhesion formation was rated macroscopically. Histologic samples were taken from previously treated areas for evaluation of eradication rate. Results: The eradication rate was not significantly different between HybridAPC treatment and sharp excision (65 vs. 81%, p =.55). Adhesions formed in 5% of HybridAPC-treated lesions and in 10% after sharp excision (p =.49). HybridAPC treatment was significantly faster than sharp excision (69 vs. 106 s, p <.05). No intra- and postoperative complications were registered. Conclusion: This clinical trial demonstrates the feasibility of this novel surgical technique with a promising impact on adhesion prevention. Compared to sharp excision, HybridAPC is likely to be a safe, tissue-preserving, and fast method for the treatment of peritoneal endometriosis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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