Decreased levels of CXCR3 transcripts in peripheral blood mononuclear cells from patients with atopic dermatitis and with cutaneous diseases associated with eosinophilia.

Autor:	Hatano, Yutaka, Katagiri, Kazumoto, Takayasu, Susumu
Předmět:	CHEMOKINES CELL receptors ATOPIC dermatitis SKIN inflammation SKIN diseases DERMATOLOGY
Zdroj:	Archives of Dermatological Research; Jun2001, Vol. 293 Issue 6, p319-322, 4p
Abstrakt:	Examines the patterns of expression of chemokine receptors that might be associated with atopic dermatitis (AD). Comparison of relative levels of messenger RNA for CCR3, CCR4, CCR5, CXCR3, interleukin-4, and interferon-&gamma in peripheral blood mononuclear cells (PBMC) from atopic patients, non-atopic patients with eosinophilia, psoriatic patients, and health controls; Detection of decreased levels of CXCR3 transcripts in PBMC from patients with AD and with cutaneous diseases associated with eosinophilia; Link between an imbalance in the expression of certain chemokine receptors and the pathogenesis of AD and various other skin diseases with eosinophilia.
Databáze:	Complementary Index
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