| Autor: |
Chalmers, A. H., Knight, P. R., Atkinson, M. R. |
| Zdroj: |
Australian Journal of Experimental Biology & Medical Science; Dec1967, Vol. 45 Issue 6, p681-691, 11p |
| Abstrakt: |
The article attempts to develop a method to show the conversion of azathioprine into mercaptopurine and mercaptoimidazole derivatives in vitro and during immunosuppressive therapy. Azathioprine 6-(1-methyl-4-nitroimidazolyl)-thiopurine was prepared for testing as an anti-neoplastic derivative of 6-mercaptopurine (6-MP). It has subsequently been found to have a chemotherapeutic index superior to that of 6-MP in suppression of the formation of haemagglutinating antibodies in mice following the injection of sheep red cells. |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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