| Autor: |
Ziyi, Liu, Xuanxuan, Shi, Dongjian, Li, Azmoun, Sajjad, Shaohua, Liu |
| Předmět: |
|
| Zdroj: |
Phlebology; Dec2022, Vol. 37 Issue 10, p701-708, 8p |
| Abstrakt: |
Objective: To study the role of hyaluronic acid (HA) in polidocanol (POL) foam. Methods: The dose-dependent effect of HA-POL on cultured human umbilical vein endothelial cells (HUVECs) as well as foam stability was evaluated by measuring optical density (OD) values and foam half-life time (FHT), respectively. An in vitro model was utilized for estimating the foam blood-displacement capacity by adopting maximum displacement distance (MDD) and displacement time. A comparison of foam viscosity was also carried out. Results: The OD values of HUVECs treated with HA first increased and then decreased with the growing dosage of HA while cells treated with HA-POL died. Both FHT and displacement time were prolonged statistically with a gradually enhanced foam viscosity. As to MDD, there were no significant differences. Conclusions: HA was found to promote HUVECs proliferation slightly, but this was almost negligible when compared to the cell-killing capacity of 1% POL. The viscosity of POL foam was enhanced by HA indicating its positive correlation with both stability and displacement capacity of POL foam. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
