| Abstrakt: |
Recently, the use of medicinal plants including effective therapeutic molecules has become of the highest priority in treating various diseases and toxicities. The aim of the present study was to undertake the beneficial effect of Rhamnus alaternus L. aqueous extract (RAAE) against aluminum chloride-induced sub-chronic hematotoxicity and renal oxidative damage in rats. DPPH free radical scavenging, β-carotene bleaching, ferric-reducing antioxidant power (FRAP), phenolic, flavonoid, and tannin contents were measured in RAAE. Twenty-four male rats were divided into four groups. The first group was used as controls, and the other three groups received daily orally 50-mg AlCl3/kg b. wt, 250-mg RAAE/kg b. wt, and AlC3 plus RAAE, respectively, for 4 weeks. The findings indicated the presence of an important amount of total phenolic, flavonoids, and tannins and high-capacity antioxidant activity. The administration of AlCl3 caused induction of hematotoxicity evidenced by a significant decrease in hematocrit (Ht), hemoglobin concentration (Hb), red blood cell count (RBC), mean corpuscular volume (MCV), and mean corpuscular hemoglobin concentration (MCHC). In addition, AlCL3 led to nephrotoxicity and oxidative stress occurrence, which were revealed by an increase of urea, creatinine, and uric acid, depletion of reduced glutathione concentration, superoxide dismutase, catalase, and glutathione peroxidase activities along with an increased level of the malondialdehyde level. However, the supplementation of RAAE significantly restored the previous mentioned parameters approximately to their normal values. These results were identical with the histological observations. In conclusion, the results showed that RAAE had efficient antioxidant properties due to its richness of antioxidant compounds, which played an important role against AlCl3-induced sub-chronic hematotoxicity and oxidative nephrotoxicity. [ABSTRACT FROM AUTHOR] |
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