Socio‐economic outcomes among long‐term childhood acute lymphoblastic leukaemia survivors enrolled between 1971 and 1998 in EORTC CLG studies: Results of the 58LAE study.
| Autor: | Barbati, Melissa, Kicinski, Michal, Suciu, Stefan, Mazingue, Françoise, Vandecruys, Els, Plat, Geneviève, Uyttebroeck, Anne, Paillard, Catherine, Dresse, Marie‐Françoise, Simon, Pauline, Pluchart, Claire, Minckes, Odile, Ferster, Alina, Freycon, Claire, Millot, Frederic, Van Der Werff ten Bosch, Jutte, Chantrain, Christophe, Paulus, Robert, de Schaetzen, Gaetan, Rossi, Giovanna |
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| Předmět: |
LYMPHOBLASTIC leukemia prognosis
LYMPHOBLASTIC leukemia treatment CANCER patient psychology CONFIDENCE intervals UNEMPLOYMENT LYMPHOBLASTIC leukemia TUMORS in children PATIENTS' attitudes COMPARATIVE studies SOCIAL classes QUESTIONNAIRES DESCRIPTIVE statistics EMPLOYMENT RESEARCH funding HEMATOPOIETIC stem cell transplantation ODDS ratio MARITAL status STATISTICAL sampling EDUCATIONAL attainment ADULTS |
| Zdroj: | European Journal of Cancer Care; Nov2022, Vol. 31 Issue 6, p1-11, 11p |
| Abstrakt: | Objective: The objective of this study is to evaluate the socio‐economic outcomes of survivors of childhood acute lymphoblastic leukaemia (ALL). Methods: Childhood ALL adult survivors, enrolled in EORTC trials between 1971 and 1998 in France and Belgium, were invited to fill out a questionnaire with information about their socio‐economic situation (living with a partner, having a university degree, having a job, working part time and history of having a paid job). The outcomes were compared with two matched control populations. Results: Among 1418 eligible patients, 507 (35.8%) participated, including 39 (8%) and 61 (12%) patients who received a haematopoietic stem cell transplantation (HSCT) and a cranial radiotherapy (CRT), respectively. The median time to follow‐up was 20 years, and median age was 25 years. Survivors showed a socio‐economic level at least as good as controls. HCST and CRT were associated with a higher probability of not obtaining a bachelor degree (respectively OR = 3.49, 95% CI: 1.46–8.35 and OR = 2.31, 95% CI: 1.04–5.15), HSCT was associated with unemployment (OR = 2.89, 95% CI: 1.09–7.65) and having a relapse was associated with a higher probability of not having a partner (OR = 1.88, 95% CI: 1.01–3.51) adjusting for confounders. Conclusion: Childhood ALL survivors showed a high level of socio‐economic participation. HCST and CRT were associated with poorer functioning. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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