| Autor: |
Trahair, Laurence G, Nauck, Michael A, Wu, Tongzhi, Stevens, Julie E, Buttfield, Madeline D, Hatzinikolas, Seva, Pham, Hung, Meier, Juris J, Rayner, Christopher K, Horowitz, Michael, Jones, Karen L |
| Předmět: |
|
| Zdroj: |
Experimental & Clinical Endocrinology & Diabetes; Nov2022, Vol. 130 Issue 11, p751-757, 7p |
| Abstrakt: |
Introduction Breath tests utilising13 C-labelled substrates for the assessment of gastric emptying have been applied widely. Wagner-Nelson analysis is a pharmacokinetic model that can be utilised to generate a gastric emptying curve from the %13 CO2 measured in breath samples. We compared Wagner-Nelson analysis with (i) scintigraphy and (ii) conventional breath test modelling to quantify gastric emptying in type 2 diabetes. Methods Thirteen patients (age 68.1±1.5 years, body mass index 31.0±0.9 kg/m2 , HbA1c 6.3±0.2%) consumed a mashed potato meal comprising 65 g powdered potato, 20 g glucose, 250 ml water, an egg yolk labelled with 100 μL13 C-octanoic acid and 20MBq99m Tc-calcium phytate. Scintigraphic data were acquired and breath samples collected for 4 hours after the meal. Gastric emptying curves were derived based on each technique; the 50% emptying time and intragastric retention at 60 min were also calculated. Results With Wagner-Nelson analysis, a Kel =0.60 (the elimination constant) best approximated the scintigraphic gastric emptying curve. There was a relationship between the T50 calculated with scintigraphy and by both Wagner-Nelson Kel =0.60 (r2 =0.45, P<0.05) and conventional analysis (r2 =0.44, P<0.05). There was no significant difference in the 50% gastric emptying time for scintigraphy (68.5±4.8 min) and Wagner-Nelson Kel =0.60 (71.3±4.5 min), however, the 50% gastric emptying time calculated by conventional analysis was much greater at 164.7±6.0 min (P<0.001). Conclusion In type 2 diabetes, gastric emptying of a mashed potato meal measured using a13 C-octanoic acid breath test analysed with Wagner-Nelson Kel =0.60 closely reflects measurements obtained with scintigraphy, whereas, in absolute terms, the conventional breath test analysis does not. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
