| Autor: |
Chauhan, Ritika, Reddy, Gangasani Narasimha, Muneeswari, Muniyasamy, Arivukodi, Deivasigamani, Niveditha, Nagarajan, Usharani, Boopathy, Shobana, Chandrasekar |
| Předmět: |
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| Zdroj: |
Journal of Pharmaceutical Negative Results; 2022 Special Issue, Vol. 13, p1125-1137, 13p |
| Abstrakt: |
Background: Vascular endothelial growth factor (VEGF) is a potent angiogenic factor and was first described as an essential growth factor for vascular endothelial cells. VEGF is up-regulated in many tumours and its contribution to tumour angiogenesis is well defined. COX2 is an enzyme that speeds up the formation of substances that cause inflammation and pain. It may also cause tumour cells to grow. Some tumours have high levels of COX-2 and blocking its activity may reduce tumour growth. Also called cyclooxygenase-2 and prostaglandin-endoperoxide synthase 2. CD105 is a cell membrane glycoprotein mainly expressed on endothelial cells and overexpressed on tumour-associated vascular endothelium, which functions as an accessory component of the transforming growth factor -ß receptor complex and is involved in vascular development and remodelling. VEGF, COX2 and CD105 biomarkers could represent a selective antiangiogenic and anticancer activity. Aim: To evaluate the impact of Hesperidin onto VEGF, COX2 and CD105 tumour cell marker on the rapidly growing capillary plexus of the chick embryo chorioallantois membrane (CAM). Materials and Methods: The in-ovo CAM assay was performed for the Hesperidin and Nano-HSP against humanized VEGF, COX2 and CD105 tumour cell marker. Results: Haemorrhagic damage was induced in the capillaries, which led to the early death of the embryos. Congestion leads to reduced blood flow out from tissues, which may be localized or systemic as seen in capillaries. Upon morphological staining, with haematoxylin and eosin stain, there was evidence of mild oedema, vascular disruption and extravasation of red blood cells in the chorion. Signs of vacuolization of the covering epithelium were also observed. Conclusion: Hesperidin blocking endogenous VEGF, COX2 and CD105 by chick embryo CAM assay might represent a valuable approach to impairing or inhibiting angiogenesis in steroidogenic-derived embryonic tissues. Therefore Hesperidin shows antiangiogenic and anti-inflammatory activity that is showing anti-VEGF, anti-COX2 and anti-CD105 antibody properties. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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