| Autor: |
Mahmood, Mohammed Abed, Humadi, Anas A., Ibrahim, Salah Noori, Abbass, Hiba Y. |
| Předmět: |
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| Zdroj: |
Biochemical & Cellular Archives; Apr2022, Vol. 22 Issue 1, p1727-1732, 6p |
| Abstrakt: |
The goals of the current study are to show the pathological effects of paracetamol on the normal architectures of the kidneys of female albino rats and the role of ascorbic acid (vitamin C) to minimize the toxic effects of paracetamol. Fifteen albino female rats in this experimental study and the animals were divided into three equal groups: the first control group injected daily using normal saline for 3 weeks. The second group was injected daily with paracetamol 40 mg/kg of BW. The third group was injected with vitamin C and then paracetamol daily in dose 80mg/kg of BW IP for three weeks. All injections in the peritoneum. The animal was anaesthetised by ether and then killed. After that, the kidney was exposed, removed, and preserved in small pieces 1cm in 10% buffer formalin for histopathological examination. The result of this experimental shows bowman's capsule dilation, glomerular shrinkage, epithelial cells vacuolation and degeneration, Mesangial cells a rounded degenerated renal tissue of tubules, after giving ascorbic acid before paracetamol, this lead to decrease the histopathological lesions and the normal architectures of the kidney is still present including bowman capsule, renal tubules and glomeruli. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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