| Autor: |
Nomura, Taisuke, Fukudo, Shin, Muranaka, Motoyasu, Iwahashi, Shigetoshi, Sasaki, Masayuki, Satake, Manabu, Sasaki, Iwao, Shibata, Chikashi, Matsuno, Seiki |
| Předmět: |
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| Zdroj: |
American Journal of Gastroenterology (Springer Nature); Sep1993, Vol. 88 Issue 9, p1432-1435, 4p, 2 Graphs |
| Abstrakt: |
We report an impressive case with Zollinger-Ellison syndrome (ZES), in which stress-induced sympathetic discharge influenced serum gastrin. Our patient was 35-yr-oid female who complained of frequent and massive vomiting (more than 4000 ml of gastric juice) which was aggravated especially by psychosocial stress. Basal hypergastrinemia (1900 pg/ml) was found after the admission. The most striking finding was that laboratory stress dramatically increased serum gastrin (from 1900 to 5400 pg/ml) and plasma noradrenaline (from 180 to 1130 pg/ml). Mental arithmetic stress further enhanced hypergastrinemia (5800 pg/ml) with a concomitant increase in plasma noradrenaline (1240 pg/ml). Neostigmine (10 Mg/kg im) also increased serum gastrin up to 6100 pg/ml but propranolol (40 µg/kg iv) reduced these elevations (noradrenaline: 990 pg/ml, gastrin: 5000 pg/ml). In this case, the effect of stress on serum gastrin mimicked the effect of catecholamine infusion in ZES. These findings suggest that psychological stress induces serum gastrin secretion via β-adrenoceptor with exacerbation of symptoms in some cases with ZES. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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