| Autor: |
Xu, Huaming, Look, Thomas, Prithiviraj, Sujeethkumar, Lennartz, Daniel, Cáceres, Manuel Delgado, Götz, Katrin, Wanek, Paul, Häcker, Hans, Kramann, Rafael, Seré, Kristin, Zenke, Martin |
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| Zdroj: |
European Journal of Immunology; Nov2022, Vol. 52 Issue 11, p1859-1862, 4p |
| Abstrakt: |
Keywords: Dendritic cells; CRISPR/Cas; dCas9; HoxB8; gene regulation EN Dendritic cells CRISPR/Cas dCas9 HoxB8 gene regulation 1859 1862 4 11/07/22 20221101 NES 221101 HoxB8 multipotent progenitors (MPP) are obtained by expression of the estrogen receptor hormone binding domain (ERHBD) HoxB8 fusion gene in mouse BM cells. Additionally, HoxB8 MPP-derived DC expressed the same DC signature genes I Cebpa i , I Flt3 i , I Irf8 i , I SpiB i , I Id2 i , and I Zbtb46 i as BM-derived DC (Supporting Information Fig. In addition, mutated Cas9 deficient in nuclease activity, referred to as dead Cas9 (dCas9), fused to effector domains, such as a transcriptional activator or repressor, achieve gene activation or gene repression, respectively [4]. [Extracted from the article] |
| Databáze: |
Complementary Index |
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