The estimated disease burden of acute COVID-19 in the Netherlands in 2020, in disability-adjusted life-years.

Autor: McDonald, Scott A., Lagerweij, Giske R., de Boer, Pieter, de Melker, Hester E., Pijnacker, Roan, Mughini Gras, Lapo, Kretzschmar, Mirjam E., den Hartog, Gerco, van Gageldonk-Lafeber, Arianne B., RIVM COVID-19 surveillance, epidemiology team, Hofhuis, Agnetha, Teirlinck, Anne, van Lier, Alies, Boudewijns, Bronke, de Dreu, Miek, Valk, Anne-Wil, Jongenotter, Femke, Verstraten, Carolien, Broekhaar, Gert, Willekens, Guido
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Zdroj: European Journal of Epidemiology; Oct2022, Vol. 37 Issue 10, p1035-1047, 13p
Abstrakt: The impact of COVID-19 on population health is recognised as being substantial, yet few studies have attempted to quantify to what extent infection causes mild or moderate symptoms only, requires hospital and/or ICU admission, results in prolonged and chronic illness, or leads to premature death. We aimed to quantify the total disease burden of acute COVID-19 in the Netherlands in 2020 using the disability-adjusted life-years (DALY) measure, and to investigate how burden varies between age-groups and occupations. Using standard methods and diverse data sources (mandatory notifications, population-level seroprevalence, hospital and ICU admissions, registered COVID-19 deaths, and the literature), we estimated years of life lost (YLL), years lived with disability, DALY and DALY per 100,000 population due to COVID-19, excluding post-acute sequelae, stratified by 5-year age-group and occupation category. The total disease burden due to acute COVID-19 was 286,100 (95% CI: 281,700–290,500) DALY, and the per-capita burden was 1640 (95% CI: 1620–1670) DALY/100,000, of which 99.4% consisted of YLL. The per-capita burden increased steeply with age, starting from 60 to 64 years, with relatively little burden estimated for persons under 50 years old. SARS-CoV-2 infection and associated premature mortality was responsible for a considerable direct health burden in the Netherlands, despite extensive public health measures. DALY were much higher than for other high-burden infectious diseases, but lower than estimated for coronary heart disease. These findings are valuable for informing public health decision-makers regarding the expected COVID-19 health burden among population subgroups, and the possible gains from targeted preventative interventions. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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