Circulating mir-21 and mir-146a are associated with increased cytokines and CD36 in Algerian obese male participants.

Autor: Benbaibeche, Hassiba, Hichami, Aziz, Oudjit, Brahim, Haffaf, El Mahdi, Kacimi, Ghouti, Koceïr, Elhadj Ahmed, Khan, Naim Akhtar
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Zdroj: Archives of Physiology & Biochemistry; Dec2022, Vol. 128 Issue 6, p1461-1466, 6p
Abstrakt: The microRNAs have come up as crucial mediators of energy balance and metabolic control. CD36 is potential biomarker of obesity and metabolic syndrome. This study investigates the concentration of miR-146a and miR-21 and CD 36 in blood samples of obese and healthy young participants. We assessed the association of mir-146a and mir-21 with inflammatory states in Algerian young participants. Our study included male obese, without co-morbidities (n = 29), and healthy participants (n = 13). miRNA and CD36 expression was measured by real-time RT-PCR, respectively, in serum and blood. miR-146a and miR-21 concentrations were significantly decreased; however, CD36 expression was increased in obese subjects. Interestingly, miR-146a and miR-21 concentrations were negatively correlated to IL-6, TNF-α, and CD36 in obese participants. We demonstrate that the downregulation of miR-146a and miR-21 was associated with upregulation of inflammatory state and increased CD36 expression in obese participants. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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