| Abstrakt: |
Aldrin and Mirex are organochlorine pesticides (OCPs) considered toxic to human and animal health. Although their use has been banned for decades, these compounds persist in several environmental and food samples, including honey. This study aimed to optimize and validate a novel simple, efficient, and, mainly, low-cost sample preparation method, based on the liquid–liquid extraction with low-temperature purification (LLE-LTP), followed by gas chromatography coupled to mass spectrometry (GC–MS) analysis for simultaneous determination of Aldrin and Mirex in honey samples. The proposed method provided recovery percentages close to 100%, with relative standard deviations < 10.0%, not requiring clean-up and concentration steps. The analytical validation according to the SANTE criteria indicated that the analytical method was selective, accurate, precise, and linear from 4.0 to 200.0 μg kg−1 for Aldrin and 2.0–200.0 μg kg−1 for Mirex. The limits of quantification were 4.0 and 2.0 μg kg−1 for Aldrin and Mirex, respectively, being lower than the maximum residue limit (MRL) established by Brazilian and European legislations. The proposed method was successfully applied in honey samples from Brazil. Aldrin's residue, at a concentration below the MRL, was detected in one sample collected in a region influenced by agricultural activities. Therefore, the LLE-LTP/GC–MS may be useful to monitor the honey's quality, assess the exposure of bees, and guarantee the consumer's health and food safety, regarding contamination by Aldrin and Mirex in this commodity. [ABSTRACT FROM AUTHOR] |
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