| Autor: |
Elseidy, Sheref A., Sayed, Ahmed, Awad, Ahmed K., Mandal, Debvarsha, Mostafa, Mariam, Adigun, Aisha, Vorla, Monica, Zamani, Zarlakhta, Iqbal, Amir |
| Předmět: |
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| Zdroj: |
Egyptian Journal of Internal Medicine; 9/4/2022, Vol. 34 Issue 1, p1-10, 10p |
| Abstrakt: |
Objective: To review the efficacy and safety of proton pump inhibitors (PPIs) in gastroesophageal varices (GEVs). Methods: We searched PubMed MEDLINE, Scopus, and Web of Science for studies that measured the effect of PPI for prophylaxis and treatment of post-band ligation ulcers up to July 20, 2021. We included studies that measured the effect of PPI as treatment or prophylaxis for post-band ligation ulcers; articles that were published in peer-reviewed international journals and had enough data for qualitative and quantitative analysis were included with no language restriction. Heterogeneity was evaluated using the inconsistency (I2) and chi-squared (χ2) test. I2 > 50% was considered substantial heterogeneity in the studies, and a P value less than 0.05 was considered statistically significant. The data was continuous, and we used the standardized mean difference (MD) and risk ratio (RR) with a 95% confidence interval to assess the estimated effect measure. Results: A total of 7 studies with 2030 patients were included in our study of which 1480 participants were males (72%) and 550 females (18%). Mean age was 59.7 years old. Rebleeding post-band ligation was compared between PPI and placebo with significant favor for PPI (p = 0.00001). The pooled risk ratio was 0.53 (95% CI of 0.41, 0.68); furthermore, bleeding-related death at a 1-month period was compared between PPI and placebo with significant favor for PPI (p = 0.00001). The pooled risk ratio was significant at 0.33 (95% CI of 0.20, 0.53). The length of hospital stay postoperative was compared between PPI and placebo with cumulative mean difference of 0.13 (95% CI of −1.13, 1.39), yet without significance. Conclusions: The study suggests a twofold reduction in the risk of bleeding and a threefold reduction in the risk of bleeding-related death with the use of PPI following EVL. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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