| Autor: |
Gonçalves de Souza, Vinícius, de Araújo Nascimento, Felipe, Aguiar Ramos, Jheneffer Sonara, Alves Pedroso, Thays Millena, Moreira Duarte, Sabrina Sara, Divino da Cruz, Aparecido, Vaz Cardoso, Ludimila Paula, de Melo e Silva, Daniela, Rocha Parise, Michelle |
| Předmět: |
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| Zdroj: |
Genetics & Applications; Jun2022, Vol. 6 Issue 1, p27-37, 11p |
| Abstrakt: |
Exposure to pesticides is an important risk factor for genotoxicity in farmworkers. Once there is a possibility that genotoxicity is related to the autoimmunity process, the present study aimed to characterize genotoxicity and possible immunological alterations related to chronic and direct exposure to a complex mixture of pesticides. It employed Interleukin-6 (IL-6), Interferon-gamma (IFN-γ), IL-12 and IL-10 as biomarkers of cellular immune function. DNA damage was greater in the exposed group (p < 0.05). Both IL-6 and IL-12 were significantly increased in the exposed group (p < 0.05 and < 0.01, respectively); on the other hand, Il-10 levels were decreased (p < 0.01). Evaluation of the association between cytokine levels and epidemiological variables showed a correlation between alcohol consumption and higher levels of IL-12 (p < 0.05). In addition, negative correlation between % DNA and IFN-γ (p < 0.05) as well as % DNA and IL-6 (p < 0.05) and positive correlation was found between IL-6 levels and absolute number of T CD8+ lymphocytes (p < 0.05) as well as between IL-10 levels and absolute number of T CD4+ lymphocytes (p < 0.05). No association between all the evaluation parameters was found in the non-exposed group. The observed alterations related to chronic and direct exposure to a complex mixture of pesticides may allow the monitoring of these workers to minimize the negative impact caused on their health. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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