| Autor: |
Vyborova, Anna, Janssen, Anke, Gatti, Lucrezia, Karaiskaki, Froso, Yonika, Austin, van Dooremalen, Sanne, Sanders, Jasper, Beringer, Dennis X., Straetemans, Trudy, Sebestyen, Zsolt, Kuball, Jürgen |
| Předmět: |
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| Zdroj: |
Frontiers in Immunology; 7/7/2022, Vol. 13, p1-13, 13p |
| Abstrakt: |
γ9δ2T cells fill a distinct niche in human immunity due to the unique physiology of the phosphoantigen-reactive γ9dδ2TCR. Here, we highlight reproducible TCRd complementaritydetermining region 3 (CDR3d) repertoire patterns associated with γ9δ2T cell proliferation and phenotype, thus providing evidence for the role of the CDR3d in modulating in vivo T-cell responses. Features that determine γ9δ2TCR binding affinity and reactivity to the phosphoantigen-induced ligand in vitro appear to similarly underpin in vivo clonotypic expansion and differentiation. Likewise, we identify a CDR3δ bias in the γ9δ2T cell natural killer receptor (NKR) landscape. While expression of the inhibitory receptor CD94/NKG2A is skewed toward cells bearing putative high-affinity TCRs, the activating receptor NKG2D is expressed independently of the phosphoantigen-sensing determinants, suggesting a higher net NKR activating signal in T cells with TCRs of low affinity. This study establishes consistent repertoire-phenotype associations and justifies stratification for the T-cell phenotype in future research on g9d2TCR repertoire dynamics. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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