| Autor: |
Garnier, Louis, Vidal, Chrystelle, Chinot, Olivier, Moyal, Elisabeth Cohen-Jonathan, Djelad, Apolline, Bronnimann, Charlotte, Bekaert, Lien, Taillandier, Luc, Frenel, Jean-Sébastien, Langlois, Olivier, Colin, Philippe, Menei, Philippe, Dhermain, Frédéric, Carpentier, Catherine, Gerazime, Aurélie, Curtit, Elsa, Figarella-Branger, Dominique, Dehais, Caroline, Ducray, François |
| Předmět: |
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| Zdroj: |
Oncologist; May2022, Vol. 27 Issue 5, p414-423, 10p, 1 Black and White Photograph, 1 Diagram, 5 Charts |
| Abstrakt: |
Background Anaplastic oligodendrogliomas IDH -mutant and 1p/19q codeleted (AO) occasionally have a poor outcome. Herein we aimed at analyzing their characteristics. Methods We retrospectively analyzed the characteristics of 44 AO patients with a cancer-specific survival <5 years (short-term survivors, STS) and compared them with those of 146 AO patients with a survival ≥5 years (classical survivors, CS) included in the POLA network. Results Compared to CS, STS were older (P =.0001), less frequently presented with isolated seizures (P <.0001), more frequently presented with cognitive dysfunction (P <.0001), had larger tumors (P =.=.003), a higher proliferative index (P =.=.0003), and a higher number of chromosomal arm abnormalities (P =.=.02). Regarding treatment, STS less frequently underwent a surgical resection than CS (P =.=.0001) and were more frequently treated with chemotherapy alone (P =.=.009) or with radiotherapy plus temozolomide (P =.=.05). Characteristics independently associated with STS in multivariate analysis were cognitive dysfunction, a number of mitosis > 8, and the absence of tumor resection. Based on cognitive dysfunction, type of surgery, and number of mitosis, patients could be classified into groups of standard (18%) and high (62%) risk of <5 year survival. Conclusion The present study suggests that although STS poor outcome appears to largely result from a more advanced disease at diagnosis, surgical resection may be particularly important in this population. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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