Dietary Intake is Associated with miR-31 and miR-375 Expression in Patients with Head and Neck Squamous Cell Carcinoma.

Autor: Ferreira, Tathiany Jéssica, de Araújo, Caroline Castro, Lima, Ana Carolina da Silva, Matida, Larissa Morinaga, Griebeler, Ana Flávia Mendes, Coelho, Alexandre Siqueira Guedes, Gontijo, Antônio Paulo Machado, Cominetti, Cristiane, Vêncio, Eneida Franco, Horst, Maria Aderuza
Předmět:
Zdroj: Nutrition & Cancer; 2022, Vol. 74 Issue 6, p2049-2058, 10p, 1 Diagram, 4 Charts
Abstrakt: MicroRNAs (miRNAs) are important epigenetic regulators in head and neck squamous cell carcinoma (HNSCC), with miR-31 being considered an oncomir and miR-375, a tumor suppressor miR, which are up- and down-regulated in HNSCC, respectively. Nutrients are known to influence miRNA expression; however, this association is poorly explored in HNSCC. This work aimed to identify associations between dietary intake and the expression of miR-31 and miR-375 in patients newly diagnosed with HNSCC. The expression of miR-31 was positively associated with the consumption of iron (β = 16.65) and vitamin C (β = 0.37), and inversely associated with total sugar (β = −0.88), cholesterol (β= −0.23), vitamin B9 (β= −0.37) and zinc (β = −5.66) intake. The expression of miR-375 was positively associated with the consumption of selenium (β = 1.52), vitamin C (β = 0.17) and vitamin D (β = 13.01), and inversely associated with the consumption of added sugar (β = −0.49), phosphorus (β= −0.27) and vitamin B12 (β = −10.80). Our findings showed important associations between dietary intake and miR-31 and miR-375 expression in HNSCC, offering possible directions for further studies investigating how nutrients interfere with carcinogenesis. Supplemental data for this article is available online at https://doi.org/10.1080/01635581.2021.1990972. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje