| Autor: |
Klein, Nathalie, Rust, Selina, Randau, Lennart |
| Zdroj: |
BioSpektrum; Jun2022, Vol. 28 Issue 4, p370-373, 4p |
| Abstrakt: |
Class 1 CRISPR-Cas systems are prevalent among prokaryotes and are characterized by effector complexes that consist of multiple Cas protein subunits. Type I systems recruit the DNA nuclease Cas3 for target DNA degradation. Type IV systems exhibit CRISPR interference in the absence of DNA cleavage. These mechanisms allow for versatile genome engineering and silencing approaches. Here, we indicate advantages and drawbacks in comparison to more commonly employed Cas9-based tools. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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