A Comparative Analysis of Serum Interleukin-6 Levels in Children with Febrile Seizures and Febrile Controls.

Autor: Kumar, K. Jagadish, Kurvari, Gaurav, Kumar, H. C. Krishna, Tejashree, A., Manjunath, V. G.
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Zdroj: Journal of Neurosciences in Rural Practice; Apr2022, Vol. 13 Issue 2, p336-338, 3p
Abstrakt: Background  Febrile seizures (FSs) are the common presentations of seizures in childhood. Activation of cytokine network plays a significant role in the genesis of FSs. Interleukin (IL)-6 is often considered as key cytokine in the generation of FSs. Objectives  To compare the serum IL-6 levels in children between simple febrile seizures (SFSs) and febrile controls (FCs). Materials and Methods  This hospital-based prospective cross-sectional study was conducted in JSS Hospital, Mysuru, during a period of 21 months. A total of 83 children were included in the study. Out of which, 38 were cases of SFSs and 45 were FCs without seizures. Serum IL-6 levels were estimated in both SFS and FC groups. Results  Serum IL-6 levels were increased among children with SFSs (mean = 608.15 pg/mL) when compared with FCs (mean = 342 pg/mL), but the results are not statistically significant (p  = 0.165). In SFS and FC groups, percentage of subjects with IL-6 levels >50 pg/mL is 31.6 and 44.4%, respectively (p  = 0.16). Conclusion  Serum IL-6 levels are higher in children with SFSs compared with FCs. However, this difference did not reach statistical significance. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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