Ranitidine or dobutamine alone or combined has no effect on gastric intramucosal-arterial PCO(2) difference after cardiac surgery.

Autor:	Väisänen, O., Ruokonen, E., Parviainen, I., Bocek, P., Takala, J., Väisänen, O
Předmět:	RANITIDINE DOBUTAMINE CARDIAC surgery PATIENTS TONOMETRY BLOOD flow ADRENERGIC beta agonists ANALYSIS of variance CARBON dioxide COMBINATION drug therapy CLINICAL trials COMPARATIVE studies CORONARY artery bypass DRUG administration GASTRIC mucosa HEMODYNAMICS HYDROGEN-ion concentration RESEARCH methodology MEDICAL cooperation POSTOPERATIVE period RESEARCH EVALUATION research RANDOMIZED controlled trials BLIND experiment H2 receptor antagonists THERAPEUTICS
Zdroj:	Intensive Care Medicine; Jan2000, Vol. 26 Issue 1, p45-51, 7p
Abstrakt:	Objective: To test the hypothesis that ranitidine, either alone or in combination with dobutamine, modifies the gastric intramucosal-arterial PCO(2) difference.Design: Full factorial design (double-blinded for ranitidine).Setting: Intensive Care Unit of a university hospital.Patients: Sixty-four haemodynamically stable coronary artery bypass surgery patients.Interventions: Ranitidine (150 mg preoperatively per os and 50 mg intravenously postoperatively) and dobutamine (4 micro g. kg(-1). min(-1) for 3 h postoperatively) were administered in four randomised groups of patients: preoperative and postoperative ranitidine, either alone (n = 15) or in combination with dobutamine (n = 17), dobutamine alone (n = 15) or neither ranitidine nor dobutamine (n = 17).Measurements and Results: Gastric intramucosal-arterial PCO(2) difference was measured during the first 5 postoperative hours. No differences in the postoperative pattern of gastric intramucosal-arterial PCO(2) difference were found among the groups.Conclusions: Ranitidine and dobutamine have no effect on the gastric tonometry results on intramucosal-arterial PCO(2) difference after uncomplicated cardiac surgery. Hence, the routine use of H(2)-antagonists for gastrointestinal tonometry is not warranted. Our results must be limited to results obtained by tonometry; they do not allow any conclusions on the effects of these drugs on splanchnic blood flow or its distribution. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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