| Autor: |
Pereira, Renata Freire Alves, Andre, Lialyz Soares Pereira, Pinheiro, Felipe Ramos, Scaffo, Julia, Corrêa, Arthur Luiz, Ribeiro, Tainara Aparecida Nunes, Sachs, Daniela, Rocha, Leandro, Aguiar-Alves, Fabio |
| Předmět: |
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| Zdroj: |
Natural Product Research; May2022, Vol. 36 Issue 10, p2643-2647, 5p |
| Abstrakt: |
Staphylococcus aureus is considered the most common opportunistic pathogen in humans, capable of forming biofilm, increasing the chances of antibiotic resistance and causes several chronic diseases. Biodiversity is a source of inspiration in the search for new agents against these microorganisms. Hitherto, the efficacy of Hypericum sp. extracts as an antibacterial agent has already been demonstrated against Gram-positive and Gram-negative bacteria. In this study, we observed that until 4 µg/mL, the Hypericum brasiliense extract showed bactericidal activity against a clinical multidrug-resistant S. aureus strain (HU25) and also inhibited biofilm formation at 1/2xMIC (confirmed by SEM) and 1/4xMIC. The extract was also proportionally active against 6 h-preformed biofilm to its concentration (1/2xMIC, 1/4xMIC, p value ≤ 0.05). These promising results make Hypericum brasiliense extract a strong candidate to treat S. aureus infections, including anti-biofilm therapy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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