| Autor: |
S., Parameshwara, B., Manjula, K., Gurupadappa, Bhaktha, Geetha, G. K., Ranjith Kumar |
| Předmět: |
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| Zdroj: |
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research); 2021, Vol. 12 Issue 3, p657-662, 6p |
| Abstrakt: |
Background: Cytochrome P450 2C19 (CYP2C19) play a versatile role in the metabolism of drugs. CYP2C19*17 variant allele increases the metabolic activity of the CYP2C19 resulting in ultra-rapid metabolizers phenotype in the individuals and decreases the therapeutic levels of substrate. Studies show that there are inter-ethnic differences in allele distribution. Methods: We recruited 48 IHD patients, demographic and biochemical parameters collected and genotype for CYP2C19*17 were studied using nested PCR-restriction fragment length polymorphism (PCR-RFLP) method. Statistical analyses were carried out using SPSS software. Results: The total allelic frequency of CYP2C19*17 was found to be 20% in our study population. Among the study subjects, 4.2% were homozygous mutant, 33.3% heterozygous and 62.5% homozygous wild genotype. Conclusion: The frequency of CYP2C19*17 is less compared to other studies. This may be due to the small sample size and inter-ethnic differences. So further elaborate study is essential to evaluate the genotype-phenotype association and clinical utility of this variant. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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