| Abstrakt: |
Introduction: Inflammation plays important role in atherosclerosis which is the primary mechanism in acute coronary syndrome (ACS). Neutrophil to lymphocyte ratio (NLR) as an indication of systemic inflammation has been researched to be associated with morbidity and mortality in ACS. There are little data available about the association between NLR, levels with GRACE and TIMI risk score. Purpose of this study was to determine the association of NLR with GRACE and TIMI score in ACS patients. Methodology. A total of 1000 ACS patients were recruited into this study retrospectively from patients that admitted to Cardiology Department at Dustira Army Hospital. Patient assessment and medical record review were performed from January 2019 to January 2020. Results. The GRACE risk score was significantly higher in the group with high NLR value compared to those with moderate and low NLR value respectively 155 (132.2-178), 134 (115-156), 125 (107.5-144.25), p<0.001). Similarly, TIMI score for UAP, NSTEMI and STEMI significantly higher in the group with high NLR value compared to those with moderate and low NLR value respectively (3 (3-4), 3 (3-4), 3 (3-3), p<0.001), (5 (4-5), 4 (4-5), 4.5 (4- 5), p<0.001) and (6 (5-7), 6 (5-6), 6 (5.5-6), p<0.001). Moreover, both GRACE (r=0,402, p<0.000) and TIMI (r=0.221, r=0.234, r=0.295, in UAP, NSTEMI, and STEMI respectively, p<0.000) score showed a significant positive correlation with NLR respectively. Conclusions. NLR is convenient, inexpensive and reproducible biomarker for ACS prognosis. [ABSTRACT FROM AUTHOR] |
