| Autor: |
Esberard de Lima Beltrão, Fabyan, Carvalhal de Almeida Beltrão, Daniele, Carvalhal, Giulia, de Lima Beltrão, Fabricia Elizabeth, de Souza Braga Filho, Jair, de Brito Oliveira, Jocyel, dos Santos de Jesus, Joice, Rodríguez Machado, Gabriel Jeferson, dos Santos Silva, Hatilla, Pitangueira Teixeira, Helena Mariana, Lopes Rodrigues, Juliana, Viana de Figueiredo, Camila Alexandrina, dos Santos Costa, Ryan, Hecht, Fabio, Bianco, Antonio C., Rodrigues Gonçalves, Maria da Conceição, Ramos, Helton Estrela |
| Předmět: |
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| Zdroj: |
Journal of Clinical Endocrinology & Metabolism; Jun2022, Vol. 107 Issue 6, pe2488-e2501, 14p |
| Abstrakt: |
Context: The type 2 deiodinase and its Thr92Ala-DIO2 polymorphism have been linked to clinical outcomes in acute lung injury and pulmonary fibrosis. Objective: Our objectives were to evaluate were cumulative mortality during admission according to Thr92Ala-DIO2 polymorphism. Methods: Here we conducted an observational, longitudinal, and prospective cohort study to investigate a possible association between the Thr92Ala- DIO2 polymorphism and intrahospital mortality from COVID-19 in adult patients admitted between June and August 2020. Blood biochemistry, thyroid function tests, length of stay, comorbidities, complications, and severity scores were also studied according to Thr92Ala-DIO2 polymorphism. Results: In total, 220 consecutive patients (median age 62; 48-74 years) were stratified into 3 subgroups: Thr/Thr (n = 79), Thr/Ala (n = 119), and Ala/Ala (n = 23). While the overall mortality was 17.3%, the lethality was lower in Ala/Thr patients (12.6%) than in Thr/Thr patients (21.7%) or Ala/Ala patients (23%). The heterozygous genotype (Thr/Ala) was associated with a 47% reduced risk of intrahospital mortality whereas univariate and multivariate logistic regression adjusted for multiple covariates revealed a reduction that ranged from 51% to 66%. The association of the Thr/Ala genotype with better clinical outcomes was confirmed in a metanalysis of 5 studies, including the present one. Conclusion: Here we provide evidence for a protective role played by Thr92Ala-DIO2 heterozygosity in patients with COVID-19. This protective effect follows an inheritance model known as overdominance, in which the phenotype of the heterozygote lies outside the phenotypical range of both homozygous. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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