| Abstrakt: |
Introduction: Adverse drug reactions (ADRs) are a major cause of morbidity and mortality, and the leading cause of hospital admission. An active pharmacovilgilance program is the need of the hour in all hospitals especially in Indian setup, as ADRs cause a significant burden to the patients and also to the economy. Aims:The present study aims are to monitor and assess adverse drug reactions in patients diagnosed with Parkinsonism disease. Material and Methods: A prospective, observational study was conducted in department of pharmacology in association with department of neuromedicine. Total number patients included in the study were 150 Parkinsonism patients. Duration of study was 01 years. Parkinsonism patients were analyzed types of ADR, side effects and anti-parkinsonism drugs Results: A prospective, observational study was conducted in department of pharmacology in association with department of neuromedicine. Majority of the patients were male age group between 50 to 59 years there were 58 in males and 18 in females. Parkinsonism patients symptoms observed at the time of enrolment in the study majority of the patients having Bradykinesia 24.70% followed by Rigidity 22.35%, postural instability 16.47%, hypomania 14.11%, pain 10.58%, GI disturbances 4.70% and mood disturbances 7.05%. There are different types of ADRs but in our study we observed only three types of ADRs majority of ADR observed was type A 62.00% followed by type B 29.33% and type C 8.66%. Parkinsonism patients were prescribed with Antiparkinsonian drugs shows ADRs, in our study we observed total of 167 ADRs majority of ADRs observed was Dizziness 28.44%, followed by Dry mouth 21.55%, Dyskinesia 13.17% Akathisia & sedation 7.18%, Anorexia, Nausea & Fatigue 5.98 % and constipation 3.59%. drugs as per our study majority of Antiparkinsonian prescribed to the patients was combination of levodopa/carbidopa 76 patients followed by pramipexole 38 patients, Trihexyphenidyl 26 patients and amantadine 10 patients. Total of 150 parkinsonism patients. Conclusion:Antiparkinsonian drugs used for the treatment of Parkinsonism. As per the study majority of the patients were male in the age group of 50 - 59 having symptoms of Bradykinesia, rigidity and postural instability. Majority of patients prescribed with levodopa/carbidopa, after ADRs monitored Dizziness followed by Dry mouth, Dyskinesia, Akathisia, sedation, Anorexia, Nausea, Fatigue and constipation was observed. [ABSTRACT FROM AUTHOR] |
