| Autor: |
Signorini, Lucia, Dolci, Maria, Castelnuovo, Nicolò, Crespi, Luigia, Incorvaia, Barbara, Bagnoli, Pietro, Parapini, Silvia, Basilico, Nicoletta, Galli, Cristina, Ambrogi, Federico, Pariani, Elena, Binda, Sandro, Ticozzi, Rosalia, Ferrante, Pasquale, Delbue, Serena |
| Předmět: |
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| Zdroj: |
Journal of NeuroVirology; Feb2022, Vol. 28 Issue 1, p113-122, 10p |
| Abstrakt: |
Here we described the virological and serological assessment of 23 COVID-19 patients hospitalized and followed up in Milan, Italy, during the first wave of COVID-19 pandemic. Nasopharyngeal (NPS), anal swabs, and blood samples were collected from 23 COVID-19 patients, at hospital admission, and periodically up to discharge, for a median time of 20 days (3–83 days). RNA was isolated and tested for SARS-CoV-2 by qRT-PCR; anti-SARS-CoV-2 IgM and IgG antibody titers were evaluated in serum samples by ELISA. SARS-CoV-2 genome was detected in the NPS swabs of the 23 patients, at the admission, and 8/19 (42.1%) were still positive at the discharge. Anal swabs were positive to SARS-CoV-2 RNA detection in 20/23 (86.9%) patients; 6/19 (31.6%) were still positive at discharge. The mean time of RNA negative conversion was 17 days (4–36 days) and 33 days (4–77 days), for NPS and anal swabs, respectively. SARS-CoV-2-RNA was detected in the blood of 6/23 (26.1%) patients. Thirteen/23 (56.5%) and 17/23 (73.9%) patients were seropositive for IgM and IgG, respectively, at the admission, and the median IgM and IgG levels significantly (p < 0.05) increased after 13 days. Although the limited cohort size, our report provides evidence that SARS-CoV-2 is shed through multiple routes, with important implications in healthcare settings. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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