| Autor: |
SHARP, DONALD M., LEWIS, EMMA, BARTON, RACHEL, O'TOOLE, LORCAN, BEAVIS, ANDREW, GREENHAULGH, ANDREW, HUTTON, CLAIRE, SYKES, MARTIN, WALKER, MARY B., STEIN, MARK, WALKER, LESLIE G. |
| Předmět: |
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| Zdroj: |
Contemporary Hypnosis & Integrative Therapy; 2022, Vol. 36 Issue 1, p7-22, 16p |
| Abstrakt: |
To reduce damage to surrounding normal tissue from radiotherapy, it is important to minimize respiratory movement during the radiotherapy planning and treatment of patients with thoracic cancer. Procedure-related anxiety, pain and other psychological factors may affect respiratory parameters in a time-dependant manner, resulting in suboptimal planning and radiotherapy. Thirty-one patients with lung cancer, oesophagea[ cancer or breast cancer were randomized to the experimental intervention (HYPRE -- relaxation, autohypnotherapy and exposure in vivo) or to standard self-initiated support (SIS) (control). The primary outcome, respiratory amplitude during radiotherapy planning, was assessed objectively and repeatedly using the Varian RPM system. In addition, other respiratory parameters were assessed repeatedly during the course of radiotherapy, and quality-of-life was assessed on six occasions during the study using standardized psychometric measures. As hypothesized, patients randomized to HYPREL had a lower mean amplitude of respiration during radiotherapy planning (p=0.029). There were no significant differences in amplitude variability, respiration frequency, or frequency variability. The two groups did not differ on any of the respiratory or quality-of-life parameters during the course of radiotherapy. Levels of anxiety and depression were very low in both groups throughout the study. In conclusion, a feasible psychological intervention and protocol have been developed for use in patients undergoing thoracic radiotherapy. Initial evaluation has found the intervention to be widely acceptable and free from adverse effects. Preliminary evaluation found that the intervention reduced respiratory amplitude during radiotherapy planning, thereby optimizing planning and minimizing harm to normal tissue surrounding the tumour. These results are encouraging and provide the basis for a phase 3 randomized controlled trial. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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