| Autor: |
Cohen-Paes, Amanda de Nazaré, de Carvalho, Darlen Cardoso, Pastana, Lucas Favacho, Dobbin, Elizabeth Ayres Fragoso, Moreira, Fabiano Cordeiro, de Souza, Tatiane Piedade, Fernandes, Marianne Rodrigues, Leal, Diana Feio da Veiga Borges, de Sá, Roberta Borges Andrade, de Alcântara, Angélica Leite, Guerreiro, João Farias, Ribeiro-dos-Santos, Ândrea, dos Santos, Sidney Emanuel Batista, de Assumpção, Paulo Pimentel, dos Santos, Ney Pereira Carneiro |
| Předmět: |
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| Zdroj: |
Genes; Mar2022, Vol. 13 Issue 3, p499-N.PAG, 11p |
| Abstrakt: |
Genetic variations in PCLO have been associated with different pathologies in global literature, but there are no data regarding this gene in Native American populations. The Amazonian Native American populations have lower genetic diversity and are more different from other continental groups. We investigated 18 genetic variants in the PCLO gene in Amazonian indigenous and compared our results with the ones found in global populations, which were publicly available in the 1000 Genomes Project, gnmAD and ABraOM databases. The results demonstrated that the variants of the PCLO, especially rs17156844, rs550369696, rs61741659 and rs2877, have a significantly higher frequency in Amerindian populations in comparison with other continental populations. These data outline the singular genetic profile of the Native American population from the Brazilian Amazon region. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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