| Autor: |
Abe, Nobuya, Kono, Michihito, Kono, Michihiro, Ohnishi, Naoki, Sato, Tomoya, Tarumi, Masato, Yoshimura, Masaru, Sato, Taiki, Karino, Kohei, Shimizu, Yuka, Fujieda, Yuichiro, Kato, Masaru, Hasebe, Rie, Oku, Kenji, Murakami, Masaaki, Atsumi, Tatsuya |
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| Zdroj: |
British Journal of Haematology; Mar2022, Vol. 196 Issue 5, p1194-1204, 11p |
| Abstrakt: |
Summary: Multicentric Castleman disease–thrombocytopenia, anasarca, reticulin fibrosis of bone marrow, renal dysfunction and organomegaly (MCD‐TAFRO)—is an emergent phenotype characterized by lymphoproliferation, fluid collection, hemocytopenia and multiple organopathy. Although studies have demonstrated an aberrant blood cytokine/chemokine profile referred to as "chemokine storm", the pathogenesis remains unclear. We aimed to identify pathogenic key molecules, potential diagnostic targets and therapeutic markers in MCD‐TAFRO using serum cytokine/chemokine profiles. We performed the targeted cytokine/chemokine multiplex analysis in six cases of MCD‐TAFRO with remission or non‐remission status. We observed significant changes in serum concentrations of CCL2, CCL5, and Chitinase‐3‐like‐1 in the MCD‐TAFRO patients with active state compared to inactive state. Ingenuity pathway analysis revealed that glycogen synthase kinase 3 (GSK3) and CCR6, which is expressed in megakaryocytes, were detected as upstream positive regulators for activating MCD‐TAFRO status. More GSK3β+CCR6+ cells like megakaryocytes were detected in the bone marrow of patients with MCD‐TAFRO than in those with systemic lupus erythematosus, MCD‐not otherwise specified or autoimmune haemophagocytic lymphohistiocytosis. The cellularity of GSK3β+CCR6+ cells was correlated with disease activity, including thrombocytopenia and anaemia. In conclusion, GSK3β and CCR6 of bone marrow cells were potentially involved in the pathogenesis of MCD‐TAFRO and may act as diagnostic targets and therapeutic markers. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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