Clinical benefit of R-CHOP without splenectomy in stage I primary splenic diffuse large B-cell lymphoma.

Autor: Rajendran, Tara, Kini, Jyoti Ramanath, Abna, Aysha, Prasad, Krishna
Zdroj: BMJ Case Reports; Jan2022, Vol. 15 Issue 1, p1-3, 3p
Abstrakt: Primary splenic diffuse large B-cell lymphoma (PS-DLBCL) is a relatively rare malignancy, and there are no optimal approaches for diagnosis and management. There are less invasive splenic biopsies that effectively obviate diagnostic and elective splenectomies. We report a man in his 50s with 2-day history of pain in the abdomen and who was found to have a splenic mass on PET-CT. A CT-guided core needle splenic biopsy confirmed the diagnosis of PS-DLBCL. He was managed with six cycles of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone) alone, without splenectomy. The patient attained complete remission, and he is disease free at 6 years of follow-up. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index