| Autor: |
Siddiqi, Najmul, Tchou, Patrick, Niebauer, Mark J., Wilkoff, Bruce L., Varma, Niraj |
| Předmět: |
|
| Zdroj: |
Journal of Cardiovascular Electrophysiology; Feb2022, Vol. 33 Issue 2, p234-240, 7p, 1 Black and White Photograph, 1 Diagram, 2 Charts, 1 Graph |
| Abstrakt: |
Objective: To test whether a high defibrillation threshold (DFT) marks patients with poor outcomes which are improved when DFT is decreased by system modification (subcutaneous coil implant; SM). Background: The electrical substrate generating fast ventricular arrhythmias may generate poor outcomes among patients treated with implantable cardioverter‐defibrillators (ICDs), even when arrhythmias are treated successfully. Since patients with high DFTs have increased mortality, we contrasted survival among patients with high DFT treated with and without SM. Methods: We studied consecutive patients undergoing ICD implantation and DFT testing at Cleveland Clinic over a 14‐year period. High DFT was defined as successful defibrillation by shock strength >25 J or ≤10 J of maximal device output. Mortality was recorded using the Social Security Death Index. Survival was compared among those high DFT patients receiving SM versus the remainder. Results: Out of 6353 patients tested, 191 (3%) had high DFT (32.1 ± 3.7 J) versus 13.9 ± 4.9 J in the remainder ("acceptable DFT," p <.001). One hundred twenty‐one high DFT patients (63%; 33.3 ± 3.4 J) underwent SM, which significantly decreased DFT (24.8 ± 5.9 J; p <.001). Seventy patients (37%; 30.3 ± 3.3 J) did not undergo SM. During follow‐up, 38% (2363/6162; 7.8 yrs) patients with acceptable DFT died versus 48% high DFT patients (91/191; 5.6 yrs.; p <.001). Concomitantly, 48% patients with SM (58/121) died, as compared to 47% patients (33/70) without SM (p =.91); median follow‐up 4.9 yrs). Conclusion: Patients with high DFT have a higher mortality than those with acceptable DFT. The additional subcutaneous coil implant decreases DFT to an acceptable range but does not appear to improve survival. The electrical substrate underlying high DFT appears to determine survival. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
|
Nepřihlášeným uživatelům se plný text nezobrazuje |
K zobrazení výsledku je třeba se přihlásit.
|
