| Abstrakt: |
Stroke is the most common type of damage brain tissues resulting from interruption of blood supply . It is divided into Ischemic Stroke and hemorrhagic Stroke. The high prevalence of the disease is very disabling and deadly that poses a serious hazard to of patients health. During or after the progression of a Stroke, pathogenesis of effect of many body products. Study of these parameters maybe helpful for determined the therapy and dose that could be given for patients, as well as to could work to prevent Stroke incidence and to reduce risk actors. The study aimed to assess Renalase, Copeptin, NT-proBNP and MMP-9 concentration levels in Ischemic Stroke patients, and show parameters correlation with severity of Stroke and National Institutes of Health Stroke Scale (NIHSS) in Basrah, Iraq. Our study included Forty two patient with Ischemic Stroke their age (42 to 63) years old. Our study included (20 males and 22 females) that admitted to Al-Sader Educational Hospital in Al-Basrah Government of Iraq, Between November 2019 and April 2020. A control group of forty healthy individuals, with no chronic diseases, no previous of Stroke and no excluded criteria of Stroke patients group. Control range of age were (48-62) years old, including (24 men and 16 women). Our study revealed a significant increase in Copeptin, NT-proBNP and activity of MMP-9 in the Stroke patients comparing to the control p-value <0.05. The results showed that Copeptin, Renalase, NT-proBNP, MMP-9 significant increase in severe Ischemic Stroke compared to moderate Ischemic Stroke group p-value (0.0012, 0.0069, 0.0094, <0.0001) respectively. The results revealed that there is a high positive significant correlation with each of MMP-9 and NT-pro- BNP (p-value = 0.0001), as well as a positive significant correlation with Copeptin (p-value = 0.006 ). Whereas the result showed a non significant correlation with Renalase (p-value = 0.097). [ABSTRACT FROM AUTHOR] |
