| Autor: |
Jayamaha, Akila R., Herath, Nimesha D. M., Nawarathne, Lahiru C., Samarakoon, Nirmani A. W., Ranadeva, Nadeeka D. K., Dharmarathna, Nishadi D., Buddhini, Divithuragamage H., Priyadarshani, Nirmala, Senarath, Samanthi N., Arachchi, Piyumali S., Samarasinghe, Kerstin L., Fernando, Neluka |
| Předmět: |
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| Zdroj: |
Critical Care Innovations; 2021, Vol. 4 Issue 4, p19-33, 15p |
| Abstrakt: |
The abundance of pharmacological interventions to treat substance abuse disorder has solidified globally. Despite promising effects, use of pharmacological interventions in substance abuse disorder are limited in asian territories. This study aimed to identify and explore existing effective pharmacological interventions on abstinence of substance abuse disorder. A systematic review was conducted adhering to PRISMA guidelines. Google scholar, Pubmed, Hinari, and Cochrane databases were systematically searched and the topic and abstract of the articles were screened for eligibility. Articles of empirical studies on pharmacological interventions on abstinence of substance abuse disorder, which were published in peer-reviewed journals during 2010 to 2020, written in English, were included and articles on alcohol and smoking cessation were excluded from the review. Full papers were then assessed against eligibility criteria. Quality appraisal and data extraction of the selected articles were performed by two independent reviewers and discrepancies were discussed with another independent reviewer to reach consensus. Three hundred and seven research articles were identified through a comprehensive database search. After screening the topics and abstracts of the articles and assessing the relevant full texts for eligibility, 26 articles of the empirical studies were included in the systematic review. High doses of Buprenorphine, Methadone, Lofexidine, Naltrexone, SB-334867, Prazosin, and Baclofen were identified to be significantly effective in abstinence from substance abuse. It was concluded that empirical evidence of effective pharmacological interventions exists and its combination with existing non-pharmacological rehabilitation interventions are proposed as more effective in the treatment of substance abuse. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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