| Autor: |
Schulmann, Karsten, Hollerbach, Stephan, Kraus, Katja, Willert, Jörg, Vogel, Tilman, Möslein, Gabriela, Pox, Christian, Reiser, Markus, Reinacher-Schick, Anke, Schmiegel, Wolff |
| Předmět: |
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| Zdroj: |
American Journal of Gastroenterology (Springer Nature); Jan2005, Vol. 100 Issue 1, p27-37, 11p |
| Abstrakt: |
OBJECTIVES: At present, surveillance of premalignant small bowel polyps in hereditary polyposis syndromes has a number of limitations. Capsule endoscopy (CE) is a promising new method to endoscopically assess the entire length of the small bowel.METHODS: We prospectively examined 40 patients with hereditary polyposis syndromes (29 familial adenomatous polyposis (FAP), 11 Peutz-Jeghers syndrome (PJS)). Results were compared with push-enteroscopy (PE) results in FAP and with esophagogastroduodenoscopy, PE, (MR)-enteroclysis, and surgical specimen in PJS patients.RESULTS: A total of 76% of the patients with FAP with duodenal adenomas (n= 21) had additional adenomas in the proximal jejunum that could be detected by CE and PE. Moreover, 24% of these FAP patients had further polyps in the distal jejunum or ileum that could only be detected by CE. In contrast, in FAP patients without duodenal polyps (n= 8), jejunal or ileal polyps occurred rarely (12%). CE detected polyps in 10 of 11 patients with PJS, a rate superior to all other reference procedures employed. Importantly, the findings of CE had immediate impact on further clinical management in all PJS patients.CONCLUSIONS: Our results suggest that CE may be of clinical value in selected patients with FAP, whereas in PJS, CE could be used as first line surveillance procedure.(Am J Gastroenterol 2005;100:27–37) [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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