| Autor: |
Brignone, SG, Ravetti, S, Maletto, BA, Palma, SD |
| Zdroj: |
Journal of Pharmaceutical Innovation; Dec2021, Vol. 16 Issue 4, p603-619, 17p |
| Abstrakt: |
The design of multiparticulate systems is a high-impact technological strategy in the formulation of immunomodulators for oral administration, fluid bed coating being a technique used due to its versatility and relatively low cost. Purpose: The objective of this work was to cover a solid support (Suglets® of Colorcon®) with an extract of cell wall of Saccharomyces cerevisiae through a fluidized bed system to determine the influence of operation and formulation conditions in the quality and performance of the product. This was carried out through a fractional factorial design. Methods: Evaluating the performance of the coating process, the weight gain of the spheres, the amount of process stops, and the morphological and qualitative analysis of the microparticles coated. Results and conclusion: Although more promising operating conditions were observed, this work verifies that there is not a single combination of levels of each factor that provides good results with respect to the performance of coating process. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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