| Autor: |
Derek Seto, Khan, Madiha, Bastedo, D. Patrick, Martel, Alexandre, Trinh Vo, Guttman, David, Subramaniam, Rajagopal, Desveaux, Darrell |
| Předmět: |
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| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America; 11/23/2021, Vol. 118 Issue 47, p1-8, 8p |
| Abstrakt: |
Pathogenic effector proteins use a variety of enzymatic activities to manipulate host cellular proteins and favor the infection process. However, these perturbations can be sensed by nucleotide-binding leucine-rich-repeat (NLR) proteins to activate effector-triggered immunity (ETI). Here we have identified a small molecule (Zaractin) that mimics the immune eliciting activity of the Pseudomonas syringae type III secreted effector (T3SE) HopF1r and show that both HopF1r and Zaractin activate the same NLR-mediated immune pathway in Arabidopsis. Our results demonstrate that the ETIinducing action of pathogenic effectors can be harnessed to identify synthetic activators of the eukaryotic immune system. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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