| Autor: |
Silva, Dionísio Henrique Amaral da, Barbosa, Humberto de Moura, Beltrão, Raphaelle Lima de Almeida, Silva, Clarissa de França Oliveira, Moura, Celuane Alves, Castro, Rosane Nora, Almeida, Jackson Roberto Guedes da Silva, Gomes, Dayane Aparecida, Lira, Eduardo Carvalho |
| Předmět: |
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| Zdroj: |
Natural Product Research; Nov 2021, Vol. 35 Issue 22, p4785-4788, 4p |
| Abstrakt: |
Morus nigra, popularly known as mulberry, has been traditionally used as anti-diabetic herbal medication. This study focused on hexane fraction from Brazilian M. nigra leaves (Hex-Mn) effects on digestion and absorption of carbohydrate in diabetic mice. The high-performance liquid chromatography (HPLC) analysis was performed, and showed the presence of flavonoids isoquercetin and kaempferol-3-O-rhamnoside. Hex-Mn did not alter oral glucose tolerance test; however, it prevented hyperglycemia in oral sucrose and starch tolerance test in diabetic mice. Also, Hex-Mn was more efficient to inhibit the α-glucosidase, showing lower inhibitory effect on α-amylase activity in vitro. The results suggest that Hex-Mn may delay the carbohydrate digestion, but not glucose transport through brush border membrane of the intestine, which contribute with reduction in postprandial hyperglycemia in mice. Hex-Mn has antihyperglycemic effect by attenuating the carbohydrate digestion in diabetic mice, which could be explained, at least in part, by the presence of isoquercetin and kaempferol-3-O-rhamnoside. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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