| Autor: |
Perez Ortiz, Gustavo, Sidda, John D., de los Santos, Emmanuel L. C., Hubert, Catherine B., Barry, Sarah M. |
| Předmět: |
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| Zdroj: |
Chemical Communications; 11/18/2021, Vol. 57 Issue 89, p11795-11798, 4p |
| Abstrakt: |
The antimycobacterial peptides, rufomycins, have their antibiotic activity conferred by oxidative tailoring of the cyclic peptide. Here we elucidate the roles of cytochrome P450s RufS and RufM in regioselective epoxidation and alkyl oxidation respectively and demonstrate how RufM and RufS create a complex product profile dependent on redox partner availability. Finally, we report the in vitro one pot conversion of rufomycin B to rufomycin C. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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