| Abstrakt: |
Background and Aim: The relationship between the Helicobacter pylori (H. pylori) infection and homocysteine is unclear. We evaluated the effect of H. pylori on serum homocysteine in a healthy Chinese population. Methods: A total of 21 184 individuals aged over 18 years underwent 13C/14C urease breath test (13C/14C‐UBT) and blood tests and 5042 individuals with follow‐up intervals greater than 6 months. Homocysteine levels are classified according to the Chinese expert consensus. Results: The rates of H. pylori infection of normal level, mild level, moderate level, and severe level were 40.9%, 43.8%, 45.8%, and 46.6%, respectively (P = 0.000). H. pylori infection increased the risk of higher homocysteine concentration (OR = 1.406, P = 0.000). In the case–control study, the rates of persistent negative, new infection, persistent infection, and eradication infection were 43.6%, 11.2%, 22.9%, and 22.3%, respectively. The percentage of changes in serum homocysteine levels varied significantly among the different H. pylori infection statuses only in mild level (P = 0.024). Mean changed homocysteine values were higher in the subgroup of persistent infection than in the persistent negative subgroup (P = 0.004) and the eradication infection subgroup (P = 0.034). Serum homocysteine values were elevated only in the subgroup with over 3 years interval time and persistent infection (n = 107, mean paired differences = 1.1 ± 4.6 μmol/L, P = 0.014). Conclusions: There is a relationship between H. pylori and serum homocysteine, and persistent infection leads to elevation of the latter. [ABSTRACT FROM AUTHOR] |
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